A disgusted Brad Pitt spat gum at funnyman Zack Galifianakis during an awkward interview segment for The Hangover star's Between Two Ferns spoof chat show series.

The Fury star said very little as Galifianakis hurled offensive and insensitive questions at him about his relationship with new wife Angelina Jolie and his acting talents.

When the host asked, "Is it hard for you to maintain a sun tan?", Pitt responded, "Why?", prompting the comic to quip, "Because you live in your wife's shadow."

Galifianakis then asked his guest if his romance with Jolie was "like one of those classical love stories" and referenced Friends characters Ross and Rachel, who was played by Pitt's first wife Jennifer Aniston.

When the movie hunk refused to respond, the bearded host pressed a button and the Friends theme was played.

But the final straw came when Galifianakis asked, "Do you think people focus too much on your looks and don't even realise that you're just a s**ty actor?". Pitt shot the funnyman a filthy look and then forcefully spat the gum he was chewing in his face.