Weiner was left shame-faced back in 2011 when it emerged that he had been swapping explicit snaps with a number of women over the web, despite being married.
The scandal prompted his resignation from Congress, but he made a comeback earlier this year (13) as a candidate in the New York City mayoral elections - only for his X-rated photo-swapping antics to tarnish his reputation once again.
He has so far refused to drop out of the race, but Sex and the City star Nixon admits she would like to see him stand down.
The star, who is backing Weiner's rival Bill de Blasio as Michael Bloomberg's replacement, tells E! News, "I don't really know what to say about that. I think there are people that are hoping that Anthony Weiner would get out of the race. I don't think he's going to, but it's his decision.
"He should let the voters decide. I think that's a legitimate point of view. Personally, I would like him to get out of the race, but I understand his point of view."