The Thelma & Louise actress gamely poured a bucket of freezing water over her head at the weekend (23-24Aug14) after One Direction star Harry Styles dared her to take part.
Prior to completing the feat, Sarandon nominated three others to face the challenge - actress Melissa MCCarthy, writer George Saunders, and Bowie, with whom she recently confessed to enjoying a fling during filming of their 1983 movie The Hunger.
In a short film posted on Facebook.com, the actress says, "Harry Styles, I accept your Als Ice Bucket Challenge in the hopes that we will raise funds for research and awareness of this horrible disease. I'm going to challenge Melissa MCCarthy, David Bowie, and George Saunders."
The campaign, which aims to raise awareness of Als, also known as Lou Gehrig's disease and motor neurone disease, has snowballed in recent weeks, with stars including Tom Cruise, Gwyneth Paltrow, Selena Gomez, Lady Gaga, and Lindsay Lohan all taking part.