The Under Pressure hitmaker has starred in a number of movies and Tv shows over the years, but hasn't acted on the small screen since 2007, when he voiced a royal character on hit children's cartoon SpongeBob SquarePants.
However, Hannibal creator and producer Bryan Fuller is hoping to tempt the singer to step back in front of the cameras to play Count Robert Lector on season two of the grisly programme, which is based on characters in author Thomas Harris' book Red Dragon.
Fuller tells Eonline.com, "We have reached out to David Bowie to see if he's interested and available. We would love for him to play Hannibal's uncle, who is a character from the literature and in the books."
The show runner has yet to receive a reply from Bowie's team but remains hopeful the pop icon will be interested in the acting gig.
Production on the new season of Hannibal, which stars Hugh Dancy as FBI agent Will Graham and Mads Mikkelsen as forensic psychiatrist Dr. Hannibal Lecter, is set to begin in Toronto, Canada in August (13).