Jennifer Aniston, Demi Moore and Alicia Keys will step behind the camera to direct different segments of a movie about breast cancer.
The A-listers will helm their own parts of the five-story film, entitled Project Five, for U.S. TV network Lifetime and will each tackle how the disease affects people's lives.
Aniston will also executive produce the feature alongside her former boss, Friends co-creator Marta Kauffman - who she hasn't worked with since the hit sitcom ended in 2004.
In a statement, the actress says, "Our hope with Project Five is to entertain, inform and inspire dialogue, research and prevention. Otherwise, our goals are small - we want these films to move people and empower those affected by breast cancer to stand tall through this challenge, which impacts all of our lives, no matter who we are."