Neil Patrick Harris regrets not going to college.

The 'How I Met Your Mother' star, who is set to host the Oscars later this month, admits he wishes he had gotten an education despite his success in Hollywood.

Asked about his greatest regret, he said: ''Not going to college - it'd have made me smarter and stuff.''

Meanwhile, the 41-year-old actor - who has four-year-old twins Harper and Gideon with his husband, David Burtka - has revealed his relationship is his number one priority in life, not his career.

He told Vanity Fair magazine: ''After more than 10 years, he still surprises me with his depth and makes me laugh. When he is happy my entire world is alive.

''David threw me a week-long scavenger hunt for my 40th birthday - it took me across the country. Best thing that has ever... no, could ever happen to me. He's the jam.''

Neil says his ''exquisite children'' are his greatest achievement, but his wisdom teeth are his ''most treasured possession.''

He explained: ''Oddly, I still have my four wisdom teeth. I refuse to let them go or I'll lose my wise parts.''