Mane used the social networking blog to lash out at his label bosses at Atlantic Records and a slew of stars, including Drake and Waka Flocka Flame, while he also boasted about his alleged sexual exploits with Minaj and R&B beauty Ciara.
Minaj was quick to shoot down his claims, tweeting, "May God strike me dead if I ever had sex wit that man... N**ga da way ya (sic) ugliness is set up... crackhead. Jesus strike me dead right now if I ever had sex with this animal."
She later revealed she had received an apology from Mane and shared her concerns for his wellbeing with her fans.
She wrote, "Ok Gee (Gucci Mane) called me... that was fun tho (though) I'm praying 4 (for) him. 4real (sic). He's sick and in dire need of rehab. Love".
Mane's Twitter tirade comes amid unconfirmed reports the rapper has been dropped from Atlantic Records. He is no longer listed on the label's roster on its official website.
The embattled hip-hop star, real name Radric Davis, has been dogged by legal troubles for years - he walked free from his most recent jail stint in May (13) following an arrest for an alleged probation violation. He is also due to stand trial later this year (13) over allegations he hit a soldier over the head with a bottle in an Atlanta, Georgia nightclub in March (13). Mane has pleaded not guilty.